AMBRICAN 5MG

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What is Ambrican 5mg?

Ambrican 5mg tablet is a medicine used to treat pulmonary hypertension in WHO class II or III patients. It is an endothelin receptor antagonist that blocks certain substances present in the lungs, which in turn helps lower blood pressure in the lungs.

How does Ambrican 5mg work?

This drug acts as a potent selective antagonist of type A endothelin receptors. Endothelin is a peptide synthesized in vascular smooth muscle as well as in the endothelium and is acted upon by endothelin-1, which is an endogenous chain of amino acids linked by amine bonds. Thus, the drug counteracts the action of endothelin, inhibits vasoconstriction, and lowers blood pressure.

Use of Ambrican 5mg

Pulmonary artery hypertension

Ambrican 5 mg tablets are used to treat pulmonary arterial hypertension (PAH), a condition characterized by hypertension in the blood vessels that carry blood from the heart to the lungs.

How to take Ambrican 5mg?

• Take Ambrican 5mg tablet for the dose and duration recommended by your doctor.
• Swallow it whole. Do not chew, crush or break.
• The Alphadopa tablet can be taken with or without food, but it is best to take it at a specific time.

Side Effects

• Drowsiness
• Headache
• Dry mouth
• Swelling of feet
• Fever
• Diarrhea
• Joint pain
• Skin rash
• Yellow-colored eyes or skin
• Anxiety

Dosage

Missed dose

As soon as possible, take the missed dose. When it’s time to take your next dose, skip the missed dose. Do not take twice to make up for a missed dose.

Overdose

Seek emergency treatment or see a doctor if you experience overdose symptoms, such as drowsiness or unclear speech.

Precautions Before using the medicine

• Do not drink alcohol while taking medicine.
• Use the medicine only as directed and not for any other purpose.
• It is advisable not to engage in activities that require a high level of vigilance such as driving, handling heavy equipment, etc.
• Store the medicine at room temperature away from heat, light, and moisture, and away from children and pets.

Warning

Warning for special population

Pregnant

Ambrican 5mgis not for pregnant women.

Breastfeeding

Ambrican 5mgis known to be excreted in breast milk. Recommended only when necessary. Side effects such as diarrhea and drowsiness need to be controlled.

General Warnings

Use children

Ambrican 5mg tablet is not for use in children and adolescents.

Infertility

This medication can lower sperm count in men. Talk to your doctor about the risks and benefits before starting treatment with this medicine.

Elevated liver enzymes

Treatment with Ambrican 5mg tablets can increase AST and ALT levels. It is recommended that therapy is discontinued if AST or ALT levels are more than 5 times the upper limit of normal (ULN).

Liquid overload

This medication may cause an increased risk of swelling in the ankles and feet due to fluid retention. Depending on the clinical condition, appropriate corrective action, dose adjustment, or replacement with a suitable alternative may be required.

Effective contraception

Since the Ambrican 5mg tablet can cause serious harm to the fetus, women of reproductive potential are advised to use highly effective contraception during treatment with this medicine and one month after stopping therapy to avoid pregnancy.

Interaction with Medicine

• Leflunomide
• Tizanidine
• Deferasirox
• Lomitapide

Storage

• Store at room temperature (10-30°C)
• Do not use tablets after the expiry date stated on the label/carton/bottle.